The proteasome

The proteasome

How does it work? The proteasome consists of a cylindrical 20 S catalytic chamber (see Figure), capped on one or both ends by a 19 S regulatory complex. The regulatory complex (which is made of at least 18 different subunits, six of which are ATPases; not shown in the Figure) recognizes ubiquitinated proteins and is thought to drive their unfolding, although the mechanism is not understood. The...

PKG primes the proteasome.

The Proteasome Pathway Destabilizes

Primes the Proteasome

P roteostasis, the precisely orchestrated balance between protein synthesis and degradation, plays a critical role in the maintenance of cell function. This is particularly the case for postmitotic cells such as cardiomyocytes and neurons, which rarely re-enter the cell cycle to divide and hence survive for decades. Disease-related stress can promote dysregu-lation of proteostasis, leading to a...

The ubiquitin-proteasome-system.

NOTICE: this is the author’s version of a work that was accepted for publication in Biochimica et Biophysica Acta Molecular Cell Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for pu...